Preheat the oven to 375 degrees and line a baking sheet with parchment paper.
Place the grated zucchini and carrots in a clean kitchen towel and squeeze out excess moisture. Transfer them to a large mixing bowl.
Add the ground beef, crushed saltine cracker crumbs, grated Parmesan, egg, diced onion, garlic powder, salt, and black pepper. Mix with your hands until the ingredients are evenly combined.
Shape the mixture into a loaf about 8 inches long and place it on the prepared baking sheet. Spread the ketchup evenly over the top.
Bake for 50 to 55 minutes until the internal temperature reaches 160 degrees. Let the meatloaf rest for 10 minutes before slicing.