Preheat the oven to 375°F and lightly grease a loaf pan.
In a large bowl, combine the ground beef, crumbled cornbread, onion, jalapeno, chili powder, cumin, salt, and black pepper. Mix until evenly blended.
Press the mixture firmly into the prepared loaf pan.
Bake for 45 to 50 minutes until the internal temperature reaches 160°F.
While the meatloaf bakes, stir together the avocados, cherry tomatoes, cilantro, and lime juice in a medium bowl to make the salsa.
Let the meatloaf rest for 5 minutes after baking, then slice and serve topped with the avocado salsa.