Heat the oven to 375°F. Lightly grease 8 cups of a standard muffin pan.
Cook the bacon in a skillet over medium heat until crisp. Transfer it to a paper towel-lined plate. Once cool, crumble it into small pieces.
In a large bowl, combine the ground beef, crumbled bacon, cheddar, panko, egg, diced onion, smoked paprika, garlic powder, salt, pepper, and 2 tablespoons of the barbecue sauce. Mix gently just until combined.
Divide the mixture among the 8 prepared muffin cups. Press it in lightly, leaving the tops rounded rather than packing the meat tightly.
Bake for 20 minutes. Remove the pan and spoon the remaining barbecue sauce over the tops of the muffins.
Return the pan to the oven and bake for 8 to 10 minutes more, until the centers reach 160°F. Let the muffins rest in the pan for 5 minutes before removing and serving.