Heat the oven to 375°F. Line a baking sheet with parchment paper.
Place the ground beef, breadcrumbs, egg, chopped roasted red peppers, paprika, garlic powder, salt, and black pepper in a mixing bowl. Mix with your hands until evenly combined.
Divide the mixture into four equal portions. Shape each into a small oval loaf and set them on the prepared baking sheet.
Spoon the ketchup evenly over the top of each mini meatloaf, spreading it lightly with the back of the spoon.
Bake for 25 to 30 minutes until the internal temperature reaches 160°F and the glaze looks set.