Heat the oven to 375°F and lightly grease a loaf pan.
In a large bowl, combine the ground beef, breadcrumbs, egg, onion, garlic, chipotle peppers, 2 tablespoons of the honey, salt, and pepper. Mix with your hands until evenly blended but do not overwork the meat.
Press the mixture into the prepared loaf pan and smooth the top.
Bake for 40 minutes.
While the meatloaf bakes, stir together the remaining 1 tablespoon honey, lime juice, lime zest, and apple cider vinegar in a small bowl.
Remove the meatloaf from the oven, spread the lime glaze evenly over the top, and return it to the oven for 10 more minutes.
Let the meatloaf rest 5 minutes before slicing.