Heat the oven to 375°F. Line a rimmed baking sheet with parchment paper.
In a large bowl, combine the ground turkey, cooked wild rice, egg, breadcrumbs, diced onion, chopped dried cranberries, orange zest, thyme, salt, and black pepper. Mix gently until the ingredients are evenly distributed. Avoid overmixing, which can make the loaf dense.
Shape the mixture into a compact loaf on the prepared baking sheet, about 8 inches long and 4 inches wide.
In a small bowl, stir together the cranberry sauce, orange juice, honey, and Dijon mustard. Spoon about half of the glaze over the meatloaf, spreading it across the top.
Bake for 40 minutes. Spoon the remaining glaze over the top, then bake for another 10 to 15 minutes, until the center reaches 165°F on an instant-read thermometer.
Let the meatloaf rest for 10 minutes before slicing. Spoon any glaze from the pan over the slices when serving.