Preheat the oven to 350 degrees F and lightly grease a loaf pan.
In a large mixing bowl, combine the ground beef, Italian breadcrumbs, egg, milk, minced garlic, Italian seasoning, salt, and black pepper.
Mix the ingredients with your hands until evenly combined, but avoid overworking the meat.
Transfer the mixture to the prepared loaf pan and press it into an even shape.
Spread the ketchup evenly over the top of the meatloaf.
Bake for 55 to 60 minutes until the internal temperature reaches 160 degrees F.
Remove from the oven and let the meatloaf rest for 5 minutes before slicing.