Heat the oven to 350 degrees and lightly grease a loaf pan.
Place the ground beef, eggs, shredded cheddar cheese, diced onion, yellow mustard, ketchup, garlic powder, salt, and black pepper in a large bowl.
Mix the ingredients with your hands or a spoon until everything is evenly combined, but stop as soon as it comes together.
Transfer the mixture to the prepared loaf pan and press it into an even shape.
Bake for 50 to 60 minutes until the internal temperature reaches 160 degrees.
Remove the pan from the oven and spread the sweet pickle relish evenly over the top of the loaf.
Let the meatloaf rest for 10 minutes before slicing and serving.